Perioperative medicine & outcomes
Preoperative biomarkers associated with delayed neurocognitive recovery
Main finding · Incidence of dNCR and baseline markers associated with dNCRResult — go to the resultBaseline cerebral oximetry, median [IQR] 68 [5] vs 72 [3]Authors' conclusion
Higher EEG power in the lower alpha band, lower alpha peak frequency, and lower cerebral oximetry values can be surrogates of baseline brain vulnerability.
Study context
- Population
- Adults undergoing GA at a tertiary academic centre in the USanalysed
- Participants
- 46 adults
- Exposure
- Delayed neurocognitive recovery (dNCR) vs no dNCR: baseline EEG features and cerebral oximetry
- dNCRn = 31
- Outcome
- Delayed neurocognitive recovery (dNCR; decrease of 2 scores in global MoCA between baseline and postoperative period)
Methodological detailssub-study of observational prospective cohorts, single-centre
- Sub-study of observational prospective cohorts
- Single-centre
Main finding
As reported in the abstract
Incidence of dNCR and baseline markers associated with dNCR
Baseline cerebral oximetry, median [IQR]
68 [5] vs 72 [3]
P = 0.011
Events by group
dNCR
67%
31
- Higher baseline EEG power in lower alpha band associated with dNCR, AUC
- 0.73 (95% CI 0.48-0.93)
- Lower baseline alpha peak frequency associated with dNCR, AUC
- 0.83 (95% CI 0.48-1)
Observational data: associations, not effects.
Original publication
Preoperative biomarkers associated with delayed neurocognitive recovery. J Clin Monit Comput. Published 12 September 2024. doi:10.
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