Perioperative medicine & outcomes
Electroencephalographic Biomarkers, Cerebral Oximetry, and Postoperative Cognitive Function in Adult Noncardiac Surgical Patients: A Prospective Cohort Study
Authors' conclusion
Preoperative posterior alpha power, frontal-parietal connectivity, and cerebral oximetry were not associated with cognitive function after noncardiac surgery.
Study context
- Population
- Adult (>18 yr) male and female noncardiac surgery patientsmedian age 59 (IQR 48 to 66) yr
- Participants
- 64 participants
- Outcome
- Mean postoperative T-score of 3 NIH Toolbox Cognition tests (Flanker Inhibitory Control and Attention, List Sorting Working Memory, Pattern Comparison Processing Speed); lowest average score from first 2 postoperative days
- Follow-up
- First two postoperative mornings
Methodological detailssingle-centre, observational
- Single-centre
- Observational
Main finding
As reported in the abstract
Partial correlation with postoperative cognition scores, adjusted for baseline cognition
- Preoperative relative posterior alpha power (%): ρ = −0.03, P = 0.854
- Alpha frontal-parietal connectivity (weight phase lag index): ρ = −0.10, P = 0.570
- Preoperative cerebral oximetry (%): ρ = 0.21, P = 0.246
- No significant partial correlation
Observational data: associations, not effects.
Secondary outcomes
Postoperative delirium (3-min Confusion Assessment Method; PACU and twice daily for first 3 postoperative days)
- Only intraoperative frontal-parietal theta connectivity associated with postoperative delirium (F = 4.53)
- P = 0.034
Cognitive and functional outcomes (patient-reported) · 3 months postdischarge
- No EEG or oximetry biomarkers associated with cognitive or functional outcomes
Original publication
Electroencephalographic Biomarkers, Cerebral Oximetry, and Postoperative Cognitive Function in Adult Noncardiac Surgical Patients: A Prospective Cohort Study. Anesthesiology. Published 26 June 2023. doi:10.
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