Cardiothoracic & vascular anesthesia
Cognitive Function Deterioration After Cardiopulmonary Bypass: Can Intraoperative Optimal Cerebral Regional Tissue Oxygen Saturation Predict Postoperative Cognitive Function?
Authors' conclusion
The MMSE in patients undergoing CPB declined at POD7 and recovered by POD60. Lower baseline rSO2 indicated a higher potential for MMSE decline at POD60. Inferior intraoperative mean rSO2 was related to higher postoperative relative theta activity and theta-gamma ratio, implying subclinical or further cognitive impairment.
Study context
- Population
- Adults undergoing cardiac surgery with cardiopulmonary bypass (CPB), January to August 2021
- Participants
- 60 adults
- Outcome
- Postoperative cognitive function (MMSE, qEEG)
- Follow-up
- POD7 and POD60
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
- Mini-Mental State Examination (MMSE): no significant decrease on POD7 vs preoperatively
- p = 0.09
- MMSE: POD60 significantly improved vs preoperative
- p = 0.02
- MMSE: POD60 significantly improved vs POD7
- p < 0.001
- Quantified electroencephalography (qEEG) relative theta power increased on POD7 vs preoperatively
- p < 0.001
- Relative theta power decreased on POD60 (POD7 vs POD60)
- p < 0.001
- Relative theta power on POD60 close to preoperative
- p > 0.99
- Mean rSO2 the only predictor for theta-gamma ratio
- p = 0.04
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Cognitive Function Deterioration After Cardiopulmonary Bypass: Can Intraoperative Optimal Cerebral Regional Tissue Oxygen Saturation Predict Postoperative Cognitive Function? J Cardiothorac Vasc Anesth. Published 2 February 2023. doi:10.
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