Perioperative medicine & outcomes
The Association of Fructose Metabolism With Anesthesia/Surgery-Induced Lactate Production
Main finding · Postoperative serum fructose 1-phosphate (metabolomics)Result — go to the resultMean difference −0.164 ×10 4Authors' conclusion
These results suggest that anesthesia/surgery activates fructose metabolism, producing excessive lactate in the brain that is associated with postoperative cognitive impairment.
Study context
- Population
- Patients ≥60 years having surgery under GA; 20-month-old mice exposed to sevoflurane (anesthesia/surgery) or 40% oxygen (control)plus mouse model
- Participants
- 43 patients
- Comparison
- Delayed neurocognitive recovery (dNCR) vs nondNCR patients; anesthesia/surgery vs control mice
- dNCRn = 17
- Outcome
- Postoperative serum fructose 1-phosphate (metabolomics)
Methodological detailsclinical cohort with mouse model, metabolomics, isotope labeling and metabolic flux
- Clinical cohort with mouse model
- Metabolomics
- Isotope labeling and metabolic flux
Main finding
As reported in the abstract
Mean difference
−0.164 ×10 4
P = 0.024
- Brain fructose 1-phosphate in mice, mean difference ± 0.555; P = .014
- −1.669
- Fructose inhibitors reduced increased brain lactate in mice, mean difference ± 4.36, P = .0237
- 96.0
- Fructose inhibitors reduced cognitive dysfunction after anesthesia/surgery in mice, mean difference ± 3.94, P = .0237
- 69.0
Further findings
| Outcome | Mean difference | P value |
|---|---|---|
| Brain IL-6 in mice (small subsample)Anesthesia/surgery vs Control · ± 3.44 | 88.3 | P = 0.0237 |
Brain IL-6 in mice (small subsample)
- IL-6 may function upstream in fructose activation
Original publication
The Association of Fructose Metabolism With Anesthesia/Surgery-Induced Lactate Production. Anesth Analg. Published 17 December 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →