Cardiothoracic & vascular anesthesia
One-Lung Ventilation and Postoperative Pulmonary Complications After Major Lung Resection Surgery. A Multicenter Randomized Controlled Trial
Primary resultResult — go to the resultRelative risk 3.03 95% CI 0.32–29Authors' conclusion
In conclusion, among adult patients undergoing elective lung resection, an OLV with lower tidal volume, PEEP 5 cmH2O, and ARMs and a higher tidal volume strategy resulted in low ARDS incidence and comparable postoperative complications, in-hospital length of stay, and mortality.
Study context
- Population
- Adults undergoing elective major lung resection (lobectomy or pneumonectomy), 16 Italian hospitals
- Participants
- 880 adults
- Comparison
- One-lung ventilation (OLV) with lower tidal volume (TV), positive end-expiratory pressure (PEEP) 5 cmH2O and alveolar recruitment maneuvers (ARMs) vs higher TV, no PEEP, no ARMs
- LTVn = 438
- HTVn = 442reference
- Primary endpoint
- Incidence of in-hospital acute respiratory distress syndrome (ARDS)
Methodological detailsmulticentre, single-blind
- Multicentre
- Single-blind
Primary result
As reported in the abstract
Relative risk
3.03
95% CI 0.32–29
P = 0.372
Events by treatment group
LTV vs HTV
RR 3.03 (95% CI 0.32–29); P = 0.372
Secondary outcomes
| Outcome | LTV | HTV | RR (95% CI) | P value | |
|---|---|---|---|---|---|
| In-hospital PPCs | 28.5% (95% CI 24.5–32.9) | 30.8% (95% CI 26.6–35.2) | 0.93 (0.76–1.14) | P = 0.507 | |
| 0.512Relative risk (log scale) |
Major complications, in-hospital mortality, unplanned intensive care unit (ICU) admission, ICU and in-hospital LOS
- Comparable in both groups
Original publication
One-Lung Ventilation and Postoperative Pulmonary Complications After Major Lung Resection Surgery. A Multicenter Randomized Controlled Trial. J Cardiothorac Vasc Anesth. Published 27 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →