Opioid analgesic effects on subjective well‐being in the operating theatre*
Authors' conclusion
These data suggest that opioid-induced improvement of well-being is infrequent in opioid-naïve patients.
Study context
- Population
- Day surgery patients
- Participants
- 159 vs 110
- Exposure
- Remifentanil or oxycodone infusion before GA; ratings before vs after
- Remifentaniln = 159
- Oxycodonen = 110
- Outcome
- Subjective well-being (how good and how anxious patients felt) before and after opioid infusion
Methodological detailsopen-label infusion, exploratory ordered logistic regression
- Open-label infusion
- Exploratory ordered logistic regression
Main finding
As reported in the abstract
Subjective well-being and anxiety after opioid vs pre-drug
| Group | Anxiety reduction, Cohen's d | 'Feeling good' reduction vs pre-drug, d | Anxiety reduction, d |
|---|---|---|---|
| Remifentanil | 0.21 | 0.28 | |
| Oxycodone | 0.31 |
Anxiety reduction, Cohen's d
Remifentanil0.21
Oxycodone— not stated in the abstract
'Feeling good' reduction vs pre-drug, d
Remifentanil0.28
Oxycodone— not stated in the abstract
Anxiety reduction, d
Remifentanil— not stated in the abstract
Oxycodone0.31
- Patients reported feeling intoxicated 1 min after injection (points/10)
- > 6/10
- Moderate to strong evidence against concurrent improvement in well-being (Bayes factors)
- > 6
Observational data: associations, not effects.
Further findings
Improved well-being by previous opioid exposure (exploratory)
- Opioid-naïve patients reporting feeling better after opioid injection
- 14 of the 80
- Odds of improved well-being, >2 weeks previous opioid use (aOR)
- 4.4
- Exploratory ordered logistic regressions
Original publication
Opioid analgesic effects on subjective well‐being in the operating theatre*. Anaesthesia. Published 28 June 2023. doi:10.
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