Opioid-free versus opioid-based anesthesia in laparoscopic sleeve gastrectomy: a single-center, randomized, controlled trial
Authors' conclusion
Opioid-free anesthesia hasn't shown an opioid-sparing effect in patients with obesity undergoing laparoscopic sleeve gastrectomy.
Study context
- Population
- Patients undergoing laparoscopic sleeve gastrectomy in a tertiary hospital
- Participants
- 83 patients
- Comparison
- Opioid-free anaesthesia vs opioid-based anaesthesia
- Primary endpoint
- Opioid consumption in PACU
Methodological detailssingle-centre
- Single-centre
Primary result
As reported in the abstract
PACU morphine consumption
- Not statistically significantly different between opioid-free anesthesia (OFA) and opioid-based anesthesia (OBA)
Further findings
Total postoperative morphine consumption, anti-emetic requirements up to 48 h, postoperative pain
- Not statistically significantly different between OFA and OBA
Other variables (intraoperative hemodynamic stability, time to extubation, post-anesthesia care unit (PACU) stay)
- Not statistically different between groups, except intraoperative anti-hypertensives: more OFA patients required them
Original publication
Opioid-free versus opioid-based anesthesia in laparoscopic sleeve gastrectomy: a single-center, randomized, controlled trial. Perioper Med (Lond). Published 5 February 2025. doi:10.
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