Optimal positive end-expiratory pressure reduces right ventricular dysfunction in COVID-19 patients on venovenous extracorporeal membrane oxygenation: A retrospective single-center study
Main finding · Hemodynamically significant RV dysfunctionResult — go to the resultOdds ratio 0.06 95% CI 0.01–0.27Study context
- Population
- Patients initiated on VV ECMO, March 2020 through November 2021
- Participants
- 69 patients
- Exposure
- Optimal positive end-expiratory pressure (PEEP) vs standard PEEP during VV ECMO
- Outcome
- Hemodynamically significant RV dysfunction
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Odds ratio
0.06
95% CI 0.01–0.27
P = 0.0008
By group
Optimal PEEP vs Standard PEEP
OR 0.06 (95% CI 0.01–0.27); P = 0.0008
Observational data: associations, not effects.
Further findings
Applied PEEP · day 2 of ECMO
| Outcome | Optimal PEEP | Standard PEEP | P value |
|---|---|---|---|
| Survival to decannulationHigher survival to decannulation with optimal PEEP | 72.7% | — not stated in the abstract | P = 0.022 |
— not stated in the abstract
Survival to discharge
- Survival to discharge, optimal vs standard PEEP: difference did not reach statistical significance (p = 0.211)
- 61.4% vs. 44.0%
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Optimal positive end-expiratory pressure reduces right ventricular dysfunction in COVID-19 patients on venovenous extracorporeal membrane oxygenation: A retrospective single-center study. J Crit Care. Published 8 February 2023. doi:10.
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