Cardiac arrest & resuscitation
Out-of-Hospital Cardiac Arrest Survival at Nighttime: A Nationwide Cohort Study
Main finding · Sustained ROSC (co-primary)Result — go to the resultAOR for sustained ROSC 0.85 95% CI 0.84–0.86Authors' conclusion
In this cohort study of OHCA, nighttime response was associated with lower adjusted odds of sustained ROSC, neurologically favorable survival, and postresuscitation survival.
Study context
- Population
- Adults (aged ≥18 years) with out-of-hospital cardiac arrest (OHCA) in the Cardiac Arrest Registry for Enhanced Survival, 2013–2024of 1,151,845 in registry
- Participants
- 874,415 adults
- Exposure
- Nighttime vs daytime OHCA
- Nighttimen = 241,967
- Outcome
- Sustained ROSC and neurologically favorable survival (Cerebral Performance Category score of 2 or more) (co-primary)
Methodological detailsregistry-based, multilevel mixed-effects logistic regression, mediation analysis
- Registry-based
- Multilevel mixed-effects logistic regression
- Mediation analysis
Main finding
Sustained ROSC (co-primary)
AOR for sustained return of spontaneous circulation (ROSC)
0.85
95% CI 0.84–0.86
Events by group
Nighttime vs Daytime
aOR for sustained ROSC 0.85 (95% CI 0.84–0.86)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Nighttime | Daytime | Estimate | |
|---|---|---|---|---|
| Neurologically favorable survival (co-primary) | 6.7% | 9.3% | aOR for neurologically favorable survival 0.84 (95% CI 0.82–0.86) | |
| Postresuscitation survival (patients with sustained ROSC) | aOR for postresuscitation survival 0.93 (95% CI 0.90–0.95) | |||
| 0.512Ratio (log scale) |
Mediation by prehospital response interval
- Proportion of total effect mediated by response interval (partial mediation)
- 12.6%
- Approximately
Original publication
Out-of-Hospital Cardiac Arrest Survival at Nighttime: A Nationwide Cohort Study. JAMA Netw Open. Published 1 April 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →