Respiratory failure & ventilation
Outcomes of patients aged ≥80 years with respiratory failure initially treated with non-invasive ventilation in European intensive care units before and during COVID-19 pandemic
Primary result · 30-day mortalityResult — go to the resultHazard ratio 2.18 95% CI 1.71–2.77Authors' conclusion
The outcomes of patients aged ≥80 years treated with NIV during COVID-19 pandemic were worse compared then those treated with NIV in the pre-pandemic era.
Study context
- Population
- Older adults (aged ≥80 years) admitted to European intensive care units (ICUs) due to respiratory failure697 (35.1%) primary non-invasive ventilation (NIV)
- Participants
- 1,986 adults
- Comparison
- COVID-19 vs Non-COVID
- COVID-19n = 694
- Non-COVIDn = 1,292reference
- Primary endpoint
- 30-day mortality, intubation rate and NIV failure (death or intubation within 30 days)
- Follow-up
- 30 days
Methodological detailsVIP2 and COVIP, merged cohort
- VIP2 and COVIP
- Merged cohort
Primary result
30-day mortality
Hazard ratio
2.18
95% CI 1.71–2.77
By group
COVIP vs VIP2
HR 2.18 (95% CI 1.71–2.77)
As reported in the abstract
Further findings
| Outcome | COVID-19 | Non-COVID | Estimate | |
|---|---|---|---|---|
| Intubation · 30 days | 36.9% | 17.5% | OR 2.63 (95% CI 1.74–3.99) | |
| NIV failure (death or intubation within 30 days) | 76.2% | 45.3% | OR 4.21 (95% CI 2.84–6.34) | |
| 30-day mortality, excluding patients with life supporting treatment limitation during primary NIV (sensitivity analysis) · sensitivity analysis | 52.5% | 23.4% | HR 2.64 (95% CI 1.83–3.80) | |
| 0.10.31310Ratio (log scale) |
Original publication
Outcomes of patients aged ≥80 years with respiratory failure initially treated with non-invasive ventilation in European intensive care units before and during COVID-19 pandemic. Ann Intensive Care. Published 12 September 2023. doi:10.
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