Outcomes Following Extracorporeal Membrane Oxygenation for Severe COVID-19 in Pregnancy or Post Partum
An erratum to this article was published (JAMA Netw Open, 1 May 2024 ↗)
Authors' conclusion
In this multicenter US cohort study of pregnant and postpartum patients who required ECMO for COVID-19-associated respiratory failure, most survived but experienced a high frequency of serious maternal morbidity.
Study context
- Population
- Pregnant and postpartum (up to 6 weeks) patients with SARS-CoV-2 infection who required extracorporeal membrane oxygenation (ECMO) for COVID-19 respiratory failure, 25 US hospitals, March 2020–October 2022
- Participants
- 100 participants · 25 hospitals
- Exposure
- Pregnant vs Immediately postpartum vs Postpartum
- Pregnantn = 47
- Immediately postpartumn = 21
- Postpartumn = 32
- Outcome
- Maternal mortality
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Maternal deaths, whole cohort: 16
16.0%
16.0%; 95% CI 8.2%–23.8%
Observational data: associations, not effects.
Secondary outcomes
≥1 serious maternal morbidity event
- 76 patients, whole cohort
- 76.0% (95% CI 58.9%-93.1%)
Duration of ECMO run
- Median (IQR 9-49) days, whole cohort
- 20
Safety
VTE (largest serious maternal morbidity), by ECMO timing
- VTE (largest serious maternal morbidity), by ECMO timing — VTE overall
- 39 (39.0%)
- VTE (largest serious maternal morbidity), by ECMO timing — Similar across ECMO timing
- P > .99
≥1 serious maternal morbidity event
- Patients with 1 or more serious maternal morbidity events
- 76 (76.0%; 95% CI, 58.9%-93.1%)
Original publication
Outcomes Following Extracorporeal Membrane Oxygenation for Severe COVID-19 in Pregnancy or Post Partum. JAMA Netw Open. Published 1 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →