Hemodynamics, fluids & transfusion
Outcomes following perioperative red blood cell transfusion in patients undergoing elective major abdominal surgery: a systematic review and meta-analysis
Pooled result · Short-term all-cause mortalityResult — go to the resultOdds ratio 2.72 95% CI 1.89–3.91Authors' conclusion
Perioperative blood transfusion in patients undergoing elective major abdominal surgery is associated with poorer short- and long-term postoperative outcomes.
Study context
- Population
- Patients undergoing elective major abdominal surgery (data collected January 1, 2000 to June 6, 2020)37 observational studies
- Comparison
- Perioperative RBC transfusion vs no transfusion
- Outcome
- Short-term mortality (all-cause 30-day or in-hospital mortality)
Methodological detailssensitivity analysis, No RCTs found; 39 observational studies identified
- Sensitivity analysis
- No RCTs found; 39 observational studies identified
Pooled result
Short-term all-cause mortality
Odds ratio
2.72
95% CI 1.89–3.91
P < 0.001
Transfusion vs No transfusion
OR 2.72 (95% CI 1.89–3.91); P < 0.001
As reported in the abstract
Further pooled results
| Outcome | Estimate | P value | |
|---|---|---|---|
| Short-term mortality, excluding studies not controlling for preoperative anaemia (sensitivity analysis) | OR 2.27 (95% CI 1.59–3.24) | P < 0.001 | |
| Long-term all-cause mortality | HR 1.35 (95% CI 1.09–1.67) | P = 0.007 | |
| 0.20.5125Ratio (log scale) |
Safety
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Any morbidity | 2.18 (1.81–2.64) | P < 0.001 | |
| Infectious complications | 1.90 (1.60–2.26) | P < 0.001 | |
| 0.20.5125Odds ratio (log scale) |
Original publication
Outcomes following perioperative red blood cell transfusion in patients undergoing elective major abdominal surgery: a systematic review and meta-analysis. Br J Anaesth. Published 21 September 2023. doi:10.
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