Early red blood cell transfusion strategy in septic shock among patients with cancer: the TRANSPORT randomized controlled trial
Primary resultResult — go to the resultOdds ratio 1.07 95% CI 0.60–1.90- prematurely stopped for safety concerns
- Prematurely stopped for safety concerns (designed to enroll 260)
Authors' conclusion
In cancer patients with septic shock, this trial did not demonstrate superiority of liberal over restrictive transfusion strategy.
Study context
- Population
- Adults with hematological or solid malignancies and septic shock with lactate > 2.0 mmol/L and Hb < 9.0 g/dL, 18 centres in Franceplanned 260
- Participants
- 187 adults
- Comparison
- Liberal vs Restrictive
- Liberaln = 93
- Restrictiven = 94reference
- Primary endpoint
- Lactate reduction (normalization ≤ 2.0 mmol/L or relative decrease by 30% from baseline)
- Follow-up
- 12 h
Methodological detailsmulticentre, superiority
- Multicentre
- Superiority
Primary result
As reported in the abstract
Odds ratio
1.07
95% CI 0.60–1.90
P = 0.82
By group
Liberal vs Restrictive
OR 1.07 (95% CI 0.60–1.90); P = 0.82
Secondary outcomes
28-day mortality
P = 0.34
Safety
Arterial or venous thrombotic events
P = 0.001
Original publication
Early red blood cell transfusion strategy in septic shock among patients with cancer: the TRANSPORT randomized controlled trial. Intensive Care Med. Published 19 August 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →