Hemodynamics, fluids & transfusion
Outcomes of Vasopressin-Receptor Agonists Versus Norepinephrine in Adults With Perioperative Hypotension: A Systematic Review
Study context
- Population
- Adults (≥18 years) undergoing any surgery under GA who developed perioperative hypotension
- Participants
- 719 adults · 13 RCTs
- Comparison
- Vasopressin-receptor agonists vs Norepinephrine
- Outcome
- All-cause mortality
Methodological detailsprospectively registered, Cochrane RoB-2 risk of bias assessment, Searches of MEDLINE, EMBASE, CENTRAL and Web of Science to November 28, 2023
- Prospectively registered
- Cochrane RoB-2 risk of bias assessment
- Searches of MEDLINE, EMBASE, CENTRAL and Web of Science to November 28, 2023
Pooled result
As reported in the abstract
- No significant difference in all-cause mortality
Further pooled results
ICU LOS (vasoplegic shock after cardiac surgery subgroup) · mean; vasopressin; N = 385; 2 trials
P < 0.005
| Outcome | P value |
|---|---|
| ICU LOS (vasoplegic shock after cardiac surgery subgroup)Median 120 [IQR 96-168] v 144 [96-216] hours | P = 0.007 |
- ICU LOS (vasoplegic shock after cardiac surgery subgroup): N = 385; 2 trials
Hospital LOS, AKI and AF (vasoplegic shock after cardiac surgery subgroup)
- Vasopressin associated with significantly lower hospital LOS and fewer cases of AKI and AF vs norepinephrine
AKI (terlipressin, one trial)
- Terlipressin associated with significantly lower incidence of AKI vs norepinephrine overall
MAP
- Vasopressin and norepinephrine restored MAP with no significant differences
- Vasopressin with norepinephrine associated with significantly higher MAP vs norepinephrine alone
Original publication
Outcomes of Vasopressin-Receptor Agonists Versus Norepinephrine in Adults With Perioperative Hypotension: A Systematic Review. J Cardiothorac Vasc Anesth. Published 12 March 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →