Pediatric anesthesia & critical care
Oxygen Supplementation in Pediatric Sedation: Prospective, Multicenter, Randomized Controlled Trial
Authors' conclusion
Routine oxygen supplementation prevents hypoxemia during pediatric moderate and deep sedation.
Study context
- Population
- Children (<18 yr) undergoing moderate to deep sedation for diagnostic and therapeutic procedures250 completed
- Participants
- 253 children
- Comparison
- Low-flow nasal cannula oxygen or high-flow nasal cannula oxygen vs no oxygen during sedation
- Primary endpoint
- Hypoxemia incidence (SpO2 ≤95% for >5 s)
Methodological detailsprospective, multicenter, three-arm
- Prospective
- Multicenter
- Three-arm
Primary result
As reported in the abstract
Hypoxemia
Odds ratio (95% CI)P value
Low-flow vs Control
0.184(0.067–0.503)
P = 0.001High-flow vs Control
0.026(0.003–0.207)
P < 0.001High-flow vs Low-flownot statistically lower
0.143(0.017–1.245)
P = 0.078Secondary outcomes
Rescue interventions
- Rescue interventions: P < 0.001
Safety
Sedation-related complications (e.g. desaturation, apnea)
- Lower in the Low-flow and High-flow groups than in Control
- P < 0.001
Original publication
Oxygen Supplementation in Pediatric Sedation: Prospective, Multicenter, Randomized Controlled Trial. Anesthesiology. Published 11 April 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →