Paediatric anaesthesia & critical care
Prone Positioning in Infants With Acute Bronchiolitis: The PROPOSITIS Randomized Clinical Trial
Primary resultResult — go to the resultAdjusted odds ratio 0.66 95% CI 0.40–1.07Authors' conclusion
Prone positioning in infants with moderate to severe bronchiolitis receiving HFNC support did not significantly reduce escalation of care.
Study context
- Population
- Infants aged ≤6 months admitted ≤24 hours with moderate to severe acute bronchiolitis requiring high-flow nasal cannula (HFNC) support, 15 pediatric intermediate or ICUs in France, January 2021–November 2023446 in primary analysis
- Participants
- 451 infants
- Comparison
- Prone vs supine positioning during HFNC support
- Prone positionn = 221
- Supine positionn = 230reference
- Primary endpoint
- Escalation of care to noninvasive or invasive ventilation, per prespecified criteria
- Follow-up
- First 72 hours
Methodological detailsmulticentre, open-label
- Multicentre
- Open-label
Primary result
As reported in the abstract
Adjusted odds ratio
0.66
95% CI 0.40–1.07
P = 0.09
Events by treatment group
Prone position vs Supine position
aOR 0.66 (95% CI 0.40–1.07); P = 0.09
Secondary outcomes
Secondary outcomes (treatment failure, tolerance, hospital LOS, respiratory support duration, comfort)
- Did not differ significantly between the 2 groups
Safety
Serious adverse events
- Serious adverse events: safety analysis: 2 of 180 vs 2 of 264
Original publication
Prone Positioning in Infants With Acute Bronchiolitis: The PROPOSITIS Randomized Clinical Trial. JAMA. Published 28 July 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →