Respiratory failure & ventilation
PaCO2 trajectories in mechanically ventilated patients with COVID‐19: A population‐based cohort study
Authors' conclusion
Latent class analysis of arterial blood gases in mechanically ventilated COVID-19 patients identified distinct PaCO2 trajectories, which were independently associated with mortality.
Study context
- Population
- Mechanically ventilated COVID-19 patients in 8 Intensive Care Units (ICUs), Capital Region of Copenhagen, Denmark, March 1, 2020–March 31, 202125,318 PaCO2 measurements
- Participants
- 244 participants
- Exposure
- PaCO2 trajectory classes: high isocapnic and progressively hypercapnic vs low isocapnic
- Class In = 130reference
- Class IIn = 80
- Class IIIn = 34
- Outcome
- Mortality by PaCO2 trajectory
Methodological detailsretrospective data collection, latent class trajectory analysis, multicentre
- Retrospective data collection
- Latent class trajectory analysis
- Multicentre
Main finding
As reported in the abstract
Mortality
Each group vs class IAdjusted hazard ratio (95% CI)
Class II
2.16(1.26–3.68)
Class III
2.97(1.63–5.40)
Observational data: associations, not effects.
Original publication
PaCO2 trajectories in mechanically ventilated patients with COVID‐19: A population‐based cohort study. Acta Anaesthesiol Scand. Published 23 March 2023. doi:10.
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