Respiratory failure & ventilation
Dynamic response of optic nerve sheath diameter to PaCO2 fluctuations: A prospective clinical monitoring study of the lung-brain axis
Authors' conclusion
ONSD measurements differed significantly between hypercapnic and normocapnic periods defined by PaCO₂ levels.
Study context
- Population
- Intubated, mechanically ventilated ICU patients with pneumonia
- Participants
- 60 participants
- Exposure
- Optic nerve sheath diameter (ONSD) during hypercapnia vs after normocapnia achieved
- Outcome
- ONSD (average of both eyes) in hypercapnic vs normocapnic periods
Main finding
As reported in the abstract
Mean ONSD (average of both eyes)
Hypercapnic period
4.88
mean · SD 0.31 · mm
P < 0.001
Observational data: associations, not effects.
Further findings
Correlation of ∆PaCO2 with reduction in mean ONSD
- Significant positive correlation (r), p < 0.001
- 0.538
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Dynamic response of optic nerve sheath diameter to PaCO2 fluctuations: A prospective clinical monitoring study of the lung-brain axis. J Clin Monit Comput. Published 1 June 2026. doi:10.
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