Respiratory failure & ventilation
Association of Hypercapnic and Nonrespiratory Acidemia With Hospital Mortality in Mechanically Ventilated Patients With Sepsis: A Retrospective Multicenter Cohort Study
Authors' conclusion
Hypercapnic acidemia and nonrespiratory acidemia within the first 24 hours of ICU admission are associated with increased risk of hospital mortality in mechanically ventilated patients with sepsis.
Study context
- Population
- Mechanically ventilated adults with sepsis, ANZICS CORE adult patient database, 201 ICUs, January 2006 to December 2022
- Participants
- 52,405 participants · 201 ICUs
- Exposure
- Compensated hypercapnia, hypercapnic acidemia or nonrespiratory acidemia vs normocapnia with normal pH (first 24 h of ICU stay)
- Outcome
- Hospital mortality
Methodological detailsmulticentre, binational
- Multicentre
- Binational
Main finding
As reported in the abstract
Each group vs normocapnia with normal pHOdds ratio (95% CI)P value
Compensated hypercapnia
1.39(1.24–1.55)
P < 0.001Hypercapnic acidemia
1.68(1.57–1.80)
P < 0.001Nonrespiratory acidemia
1.75(1.61–1.90)
P < 0.001Observational data: associations, not effects.
Further findings
Hospital mortality in prespecified diagnostic subgroups (subgroup)
- Increased risk with hypercapnic and nonrespiratory acidemia persisted in all prespecified diagnostic subgroups vs normal pH and normocapnia
- Compensated hypercapnia associated with increased mortality risk in neurologic and unspecified sepsis subgroups
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Association of Hypercapnic and Nonrespiratory Acidemia With Hospital Mortality in Mechanically Ventilated Patients With Sepsis: A Retrospective Multicenter Cohort Study. Crit Care Med. Published 5 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →