Pathogen-based target attainment of optimized continuous infusion dosing regimens of piperacillin-tazobactam and meropenem in surgical intensive care unit (ICU) patients: a prospective single center observational study
Authors' conclusion
Despite these pathogen-based data demonstrating that CRTA and TRA is higher than in the often-used theoretical worst-case scenario, a substantial proportion of samples did not attain commonly used PK/PD targets when using optimised continuous infusion dosing regimens.
Study context
- Population
- Surgical ICU patients receiving continuous infusion TZP or MEM, March 2016–April 2019
- Participants
- 1,036 prescriptions
- Exposure
- TZP vs MEM
- TZPn = 731
- MEMn = 305
- Outcome
- Pathogen-based clinically relevant target attainment (CRTA: corrected concentration above the pathogen break points (BP), up to 6 × BP) and therapeutic range attainment (TRA)
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Corrected plasma concentration; CRTA and TRA
Observational data: associations, not effects.
Original publication
Pathogen-based target attainment of optimized continuous infusion dosing regimens of piperacillin-tazobactam and meropenem in surgical ICU patients: a prospective single center observational study. Ann Intensive Care. Published 29 April 2023. doi:10.
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