Respiratory failure & ventilation
Pathophysiological Markers of Acute Respiratory Distress Syndrome Severity Are Correlated With Ventilation-Perfusion Mismatch Measured by Electrical Impedance Tomography
Authors' conclusion
In ARDS patients, unmatched V/Q units are correlated with pathophysiological markers of lung epithelial and endothelial dysfunction, increased lung stress, and lung edema.
Study context
- Population
- Deeply sedated intubated adults with acute respiratory distress syndrome (ARDS) under controlled mechanical ventilation, general ICU of a university-affiliated hospital
- Participants
- 25 participants
- Outcome
- Correlation of unmatched V/Q units with markers of ARDS severity
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
- Median unmatched V/Q units
- 37.1% (29.2-49.2%)
- Correlation with plasma CA9
- rho = 0.47; p = 0.01
- Correlation with plasma HIF1
- rho = 0.40; p = 0.05
- Correlation with plasma RAGE
- rho = 0.46; p = 0.02
- Correlation with plasma ANG2
- rho = 0.42; p = 0.03
- Correlation with plateau pressure
- r = 0.38; p = 0.05
- Correlation with number of quadrants involved on chest radiograph
- r = 0.73; p < 0.01
- Regional correlation with fraction of poorly aerated lung tissue on CT
- r = 0.62; p = 0.01
- Regional correlation with lung tissue weight on CT
- rho: 0.51; p = 0.04
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Pathophysiological Markers of Acute Respiratory Distress Syndrome Severity Are Correlated With Ventilation-Perfusion Mismatch Measured by Electrical Impedance Tomography. Crit Care Med. Published 24 October 2024. doi:10.
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