Peri-intubation complications in critically ill obese patients: a secondary analysis of the international INTUBE cohort
An erratum to this article was published (Crit Care, 31 Jul 2025 ↗)
Authors' conclusion
Compared to non-obese patients, obese critically ill exhibit a higher incidence of peri-intubation severe hypoxemia.
Study context
- Population
- Critically ill adults undergoing in-hospital tracheal intubation, 197 sites in 29 countries, October 2018–July 2019
- Participants
- 2,946 adults · 197 sites · 29 countries
- Comparison
- Obese vs non-obese critically ill patients
- Obesen = 639
- Non-obesen = 2,307reference
Methodological detailsinternational, multicentre
- International
- Multicentre
Primary result
As reported in the abstract
Severe peri-intubation hypoxemia
P = 0.01
Further findings
Independent predictors of peri-intubation hypoxemia
- Baseline SpO2/FiO2, OR
- 0.996 (95% CI 0.994-0.997)
- 30-45° head-up position, OR
- 1.53 (95% CI 1.04-2.26)
- First-pass success, OR
- 0.21 (95% CI 0.15-0.29)
Independent predictors of first-pass intubation failure (OR for first-pass success)
- Obesity, OR
- 0.71 (95% CI 0.56-0.91)
- 20° head-up position, OR
- 0.67 (95% CI 0.47-0.95)
- Intubation by staff physician/consultant, OR
- 1.70 (95% CI 1.30-2.21)
- Intubation by anesthesiologists, OR
- 1.98 (95% CI 1.55-2.53)
Original publication
Peri-intubation complications in critically ill obese patients: a secondary analysis of the international INTUBE cohort. Crit Care. Published 13 May 2025. doi:10.
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