Perineural and Systemic Dexamethasone and Ulnar Nerve Block Duration: A Randomized, Blinded, Placebo-controlled Trial in Healthy Volunteers
Authors' conclusion
Perineural dexamethasone as an adjunct to bupivacaine in healthy volunteers resulted in a greater duration of an ulnar nerve block when compared with placebo. Systemic dexamethasone resulted in a similar duration as placebo.
Study context
- Population
- Healthy volunteers receiving bilateral ulnar nerve blocks with 3 ml bupivacaine 5 mg/ml
- Participants
- 16 healthy volunteers
- Comparison
- Perineural or systemic dexamethasone vs placebo as adjunct to bupivacaine ulnar nerve block
- Primary endpoint
- Duration of sensory nerve block (temperature discrimination)
Methodological detailsblinded, placebo-controlled, within-subject (bilateral blocks, two trial days)
- Blinded
- Placebo-controlled
- Within-subject (bilateral blocks, two trial days)
Primary result
As reported in the abstract
Each group vs placeboMean difference, min (95% CI)
Perineural
66(23–108)
Systemic
36(−30 to 103)
Original publication
Perineural and Systemic Dexamethasone and Ulnar Nerve Block Duration: A Randomized, Blinded, Placebo-controlled Trial in Healthy Volunteers. Anesthesiology. Published 9 May 2023. doi:10.
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