Perioperative medicine & outcomes
Perioperative changes in neurocognitive and Alzheimer's disease-related cerebrospinal fluid biomarkers in older patients randomised to isoflurane or propofol for anaesthetic maintenance
Authors' conclusion
Intraoperative anaesthetic maintenance with isoflurane vs propofol had no significant effect on postoperative cognition or CSF Alzheimer's disease-related biomarkers within 6 weeks after noncardiac, non-neurological surgery in older adults.
Study context
- Population
- Patients age ≥60 yr undergoing noncardiac/non-neurological surgerycompleted 6-week follow-up, analysed
- Participants
- 107 participants
- Comparison
- Isoflurane vs propofol for anaesthetic maintenance
- Isofluranen = 54
- Propofoln = 53reference
Primary result
As reported in the abstract
Cerebrospinal fluid (CSF) Aβ, tau, phospho-tau181p levels, tau/Aβ and p-tau181p/Aβ ratios · before, 24 h, and 6 weeks after surgery
- No significant effect of anaesthetic group, time, or group-by-time interaction (all P>0.05 after Bonferroni correction)
Further findings
| Outcome | Mean difference (95% CI) | P value | |
|---|---|---|---|
| Change in overall cognition · 6 weeksMultivariable-adjusted · intention-to-treat · consistent in as-treated and per-protocol analyses | 0.01 (−0.12 to 0.13) | P = 0.89 | |
| −0.2−0.100.10.2Difference (linear scale) |
Change in individual cognitive domains · 6 weeks
- No significant differences (P>0.05 for each)
- Intention-to-treat
Original publication
Perioperative changes in neurocognitive and Alzheimer's disease-related cerebrospinal fluid biomarkers in older patients randomised to isoflurane or propofol for anaesthetic maintenance. Br J Anaesth. Published 2 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →