Pediatric anesthesia & critical care
Perioperative Complications in Multispecialty Surgical Care for Patients With Trisomy 21: A Single Center Retrospective Cohort Study
Main finding · Perioperative events, multispecialty case as independent risk factorResult — go to the resultOdds ratio 2.6 95% CI 1.6–4.3Authors' conclusion
Multispecialty care is a highly utilized method of providing care for children with T21 within our institution, often used to ease the scheduling burden and risk of these children and families.
Study context
- Population
- Children with trisomy 21 (T21) undergoing anesthesia at Children's Wisconsin over 9.6 yearscases in 995 patients
- Participants
- 3,873 children
- Exposure
- Multispecialty vs single specialty anesthesia cases
- Multispecialtyn = 1,002
- Single specialtyn = 2,871reference
- Outcome
- Perioperative safety events
Methodological detailssingle-centre, multivariable logistic regression
- Single-centre
- Multivariable logistic regression
Main finding
As reported in the abstract
Perioperative events, multispecialty case as independent risk factor
Odds ratio
2.6
95% CI 1.6–4.3
Multispecialty vs Single specialty
OR 2.6 (95% CI 1.6–4.3)
Observational data: associations, not effects.
Further findings
T21 cohort vs whole anesthesia population (n = 120 299 patients, 219 626 cases)
- Multiple anesthetics per patient, OR (95% CI 7.11-9.04), p < 0.001
- 8.02
- Multispecialty care, OR (95% CI 3.6-4.3), p < 0.001
- 3.95
- Perioperative safety events, OR (95% CI 4.51-7.08), p < 0.001
- 5.65
Other independent risk factors for perioperative events (multivariable)
- ASA-PS 4, OR
- 4.5 (95% CI 1.4-14.5)
- ASA-PS 5, OR
- 85.5 (95% CI 22.8-320.3)
- Black or African American race, OR
- 1.98 (95% CI 1.2-3.3)
- Anesthesia time, OR
- 1.22 (95% CI 1.1-1.3)
- No increased risk with number of anesthetics per patient
Original publication
Perioperative Complications in Multispecialty Surgical Care for Patients With Trisomy 21: A Single Center Retrospective Cohort Study. Paediatr Anaesth. Published 7 March 2026. doi:10.
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