Pediatric anesthesia & critical care
The Association of Guideline-Directed Prophylaxis with Postoperative Nausea and Vomiting in Pediatric Patients: A Single-Center, Retrospective Cohort Study
Authors' conclusion
Guideline-directed PONV prophylaxis is inconsistently associated with incidence of PONV across the guideline-defined risk spectrum.
Study context
- Population
- Pediatric general anesthetic cases, 2018 to 2021
- Participants
- 14,747 cases
- Exposure
- Adequate vs inadequate guideline-directed postoperative nausea and vomiting (PONV) prophylaxis
- Outcome
- PONV (documented postoperative nausea/emesis or rescue antiemetic)
Methodological detailssingle-centre, propensity score weighting, Bayesian binomial models
- Single-centre
- Propensity score weighting
- Bayesian binomial models
Main finding
As reported in the abstract
Adequate prophylaxis vs InadequateWeighted median odds ratio (95% CrI)
Probability of benefit, 0.97
0.82(0.66–1.02)
- Adequate prophylaxis
- weighted marginal absolute risk reduction 1.3% (95% CrI −0.1% to 3.1%)
Observational data: associations, not effects.
Further findings
PONV by sum of risk factors (subgroup), unweighted
- Reduced incidence with 1 to 2 risk factors, probability of benefit
- 0.96 and 0.95
- Increased incidence with 3, 4, and 5 risk factors, probability of benefit
- 0, 0.01, and 0.03
- Interaction between sum of risk factors and association of adequate prophylaxis with PONV
PONV by sum of risk factors (subgroup), weighted
- Persistent benefit with 1 to 2 risk factors, probability of benefit
- 0.90 and 0.94
- Equalization of risk with 3+ risk factors
Original publication
The Association of Guideline-Directed Prophylaxis with Postoperative Nausea and Vomiting in Pediatric Patients: A Single-Center, Retrospective Cohort Study. Anesth Analg. Published 17 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →