Perioperative medicine & outcomes
Supplemental intraoperative crystalloids for pediatric postoperative nausea and vomiting—A systematic review and meta‐analysis
Pooled result · Postoperative vomitingResult — go to the resultRelative risk 0.56 95% CI 0.39–0.80Authors' conclusion
Supplemental intraoperative intravenous crystalloids significantly reduce several PONV outcomes in healthy children undergoing relatively simple and superficial surgeries under volatile agent-based general anesthesia.
Study context
- Population
- Patients ≤18 years undergoing elective surgery under GA
- Participants
- 864 patients · 7 RCTs
- Comparison
- Supplemental vs conventional intraoperative IV crystalloid fluid therapy
- Outcome
- Postoperative vomiting
Methodological detailsrandom or fixed effects model
- Random or fixed effects model
Pooled result
As reported in the abstract
Relative risk
0.56
95% CI 0.39–0.80
P = 0.001
Supplemental vs Conventional
RR 0.56 (95% CI 0.39–0.80); P = 0.001
Further pooled results
| Outcome | RR (95% CI) | P value | |
|---|---|---|---|
| PONV | 0.52 (0.37–0.74) | P = 0.0003 | |
| Postoperative thirst | 0.21 (0.13,0.34) | P < 0.01 | |
| Need for rescue anti-emetics | 0.60 (0.49–0.74) | P = 0.00001 | |
| 0.10.31310Relative risk (log scale) |
Original publication
Supplemental intraoperative crystalloids for pediatric postoperative nausea and vomiting—A systematic review and meta‐analysis. Paediatr Anaesth. Published 8 October 2022. doi:10.
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