Perioperative medicine & outcomes
Perioperative Supplemental Oxygen and Postoperative Nausea and Vomiting: Subanalysis of a Trial, Systematic Review, and Meta-analysis
Pooled result · PONVResult — go to the resultRelative risk 1.04 95% CI 0.96–1.12Authors' conclusion
The incidence of postoperative nausea and vomiting did not differ in patients assigned to 80% or 30% inspired oxygen. A meta-analysis of available trials similarly indicated that supplemental intraoperative oxygen does not reduce postoperative nausea and vomiting.
Study context
- Population
- Adults recovering from colorectal surgery at the Cleveland Clinic, January 28, 2013–March 11, 2016surgeries on 4,001 patients
- Participants
- 5,057 adults
- Comparison
- 80% vs 30% intraoperative inspired oxygen
- 80% oxygenn = 2,554
- 30% oxygenn = 2,503reference
- Outcome
- Incidence of postoperative nausea and/or vomiting
Methodological detailsunplanned subanalysis, generalized estimating equation model
- Unplanned subanalysis
- Generalized estimating equation model
Pooled result
PONV
Relative risk
1.04
95% CI 0.96–1.12
P = 0.355
Events by group
80% oxygen vs 30% oxygen
RR 1.04 (95% CI 0.96–1.12); P = 0.355
As reported in the abstract
Further pooled results
| Outcome | P value |
|---|---|
| Antiemetic useSupplemental oxygen did not reduce antiemetic use | P = 0.911 |
| Severity of nausea and vomitingSupplemental oxygen did not reduce severity | P = 0.924 |
PONV, meta-analysis (10 trials, 6,749 patients)
- No difference in PONV: RR (95% CI 0.86 to 1.08), P = 0.55
- 0.97
- I2 = 52%
Original publication
Perioperative Supplemental Oxygen and Postoperative Nausea and Vomiting: Subanalysis of a Trial, Systematic Review, and Meta-analysis. Anesthesiology. Published 1 November 2022. doi:10.
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