Pediatric anesthesia & critical care
Perioperative considerations in the paediatric patient with congenital and acquired coagulopathy
Study context
- Population
- Neonates, infants and children with congenital or acquired coagulopathy undergoing major surgery or with trauma
Main finding
As reported in the abstract
- Neonates and infants at highest risk of severe perioperative coagulopathy (immature haemostatic system; inherited bleeding disorders may be undiagnosed before surgery)
- Viscoelastic testing increasingly used to monitor coagulopathy, but valid age-specific reference values and trigger or target values are lacking
- In vitro closure time by platelet function analyser is a promising screening tool for quantitative and qualitative platelet abnormalities
- Targeted individualised treatment may include TXA, plasma-derived or recombinant factors (e.g. fibrinogen concentrate), or allogeneic blood components (plasma, platelets, cryoprecipitate)
Original publication
Perioperative considerations in the paediatric patient with congenital and acquired coagulopathy. BJA Open. Published 23 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →