Perioperative medicine & outcomes
Perioperative Management and Outcome of Catecholamine-Induced Takotsubo and Dilated Cardiomyopathy in Pheochromocytoma and Paraganglioma
Authors' conclusion
Following the preoperative medication preparation and anti-heart failure treatment, patients with TCM had better left ventricular recovery before surgery and fewer cardiovascular risks compared to patients with DCM.
Study context
- Population
- Patients scheduled for elective PPGL resection with Takotsubo cardiomyopathy (TCM) or dilated cardiomyopathy (DCM), single tertiary hospital, March 2005–June 2023
- Participants
- 29 patients
- Exposure
- TCM vs DCM
- TCMn = 20
- DCMn = 9reference
- Outcome
- Preoperative ejection fraction (after medication preparation and anti-HF treatment)
- Follow-up
- Mean preoperative
Methodological detailssingle-centre, Preoperative medication preparation 111 median days
- Single-centre
- Preoperative medication preparation 111 median days
Main finding
As reported in the abstract
P < 0.001
Observational data: associations, not effects.
Further findings
Tumour size and 24-hour urine norepinephrine
- Bigger tumour size and higher 24-hour urine norepinephrine in DCM vs TCM
Intraoperative hemodynamic instability score (all patients)
- Hemodynamic instability score (points)
- 84.6
- Hemodynamic variables section (points)
- 13.7
Intraoperative hemodynamics, fluids and vasoactive agents
- DCM more prone to hemodynamic disturbances, lower fluid volume but higher vasoactive infusion vs TCM
Complications and perioperative mortality (all patients)
- Incidence of complications
- 6.9%
- Perioperative mortality
- 0
Original publication
Perioperative Management and Outcome of Catecholamine-Induced Takotsubo and Dilated Cardiomyopathy in Pheochromocytoma and Paraganglioma. J Cardiothorac Vasc Anesth. Published 5 February 2025. doi:10.
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