Perioperative medicine & outcomes
Primary perioperative haemodynamic effects of ß-receptor blockade in patients with catecholamine-secreting tumours
Authors' conclusion
Overall, patients with isolated ß-receptor blockade developed higher blood pressure before operation and intraoperatively. After propensity score matching a difference could no longer be detected.
Study context
- Population
- Patients undergoing phaeochromocytoma and paraganglioma resection without α-receptor blockadeof 584 resections
- Participants
- 383 patients
- Exposure
- ß-receptor blockade vs Without ß-receptor blockade
- ß-receptor blockaden = 84
- Outcome
- Highest pre-, intra- and postoperative SBP
Methodological detailspropensity-score matched analysis
- Propensity-score matched analysis
Main finding
As reported in the abstract
Highest SBP
| Group | Value | Intraoperative |
|---|---|---|
| ß-blockade | 155 (SD 25) mm Hg | 207 [62] mm Hg |
| No ß-blockade | 147 (SD 24) mm Hg | 183 [52] mm Hg |
Value
ß-blockade155 (SD 25) mm Hg
No ß-blockade147 (SD 24) mm Hg
Intraoperative
ß-blockade207 [62] mm Hg
No ß-blockade183 [52] mm Hg
- ß-blockade vs No ß-blockade: P = 0.006 — preoperative
- ß-blockade vs No ß-blockade: P = 0.001 — intraoperative
Observational data: associations, not effects.
Secondary outcomes
| Outcome | ß-receptor blockade | P value |
|---|---|---|
| Intraoperative hypotensive episodesß-blockade vs No ß-blockade · no difference after propensity score matching | 41% | P < 0.001 |
- Intraoperative hypotensive episodes: No ß-blockade 25%
Original publication
Primary perioperative haemodynamic effects of ß-receptor blockade in patients with catecholamine-secreting tumours. BJA Open. Published 6 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →