Pediatric anesthesia & critical care
Perioperative management and outcomes for posterior spinal fusion in patients with Friedreich ataxia: A single‐center, retrospective study
Authors' conclusion
Patients with Friedreich ataxia are at high risk for perioperative complications when undergoing posterior spinal fusion and coordinated multidisciplinary care is required at each stage.
Study context
- Population
- Adolescents with Friedreich ataxia undergoing posterior spinal fusion, Children's Hospital of Philadelphia, 2007–2023included in final analysis
- Participants
- 17 adolescents
- Outcome
- Perioperative management and outcomes
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
- Intraoperative TEE monitoring
- 53%
- Changes in volume status on echo, no changes in function
- 12%
- Wake-up tests (poor baseline neuromonitoring signals in 4, signal loss in 1)
- 4 (24%)
- Extubated in the operating room
- 75%
- Postoperative complications
- 88%
Observational data: associations, not effects.
Further findings
Preoperative characteristics
- Age, mean ± SD (years)
- 15 ± 2
- Female
- 47%
- Wheelchair dependent
- 35%
- Mild-to-moderate hypertrophic cardiomyopathy, preserved systolic function, no LV outflow tract obstruction
- 100%
- On cardiac medications
- 29%
- On pain medications
- 29%
Anesthetic agents
- Numerous TIVA combinations; most commonly propofol, remifentanil and ketamine
Safety
- Any postoperative complication
- 88%
- Nausea/vomiting
- 18%
- Hypotension/tachycardia
- 29%
- ECMO support
- 6%
- ECMO in one patient
Original publication
Perioperative management and outcomes for posterior spinal fusion in patients with Friedreich ataxia: A single‐center, retrospective study. Paediatr Anaesth. Published 24 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →