Pediatric anesthesia & critical care
Perioperative methadone for posterior spinal fusion in adolescents: Results from a double‐blind randomized‐controlled trial
Primary result · Total postoperative opioid consumptionResult — go to the resultMedian difference −0.07 95% CI −0.2 to 0.02Authors' conclusion
A two-dose intraoperative methadone regimen resulted in decreased opioid consumption compared to morphine.
Study context
- Population
- Adolescents undergoing posterior spinal fusion
- Participants
- 47 adolescents
- Comparison
- Intraoperative methadone vs morphine
- Methadonen = 25
- Morphinen = 22reference
- Primary endpoint
- Postoperative opioid consumption
Methodological detailssingle-centre, double-blind, stratified by sex
- Single-centre
- Double-blind
- Stratified by sex
Primary result
Total postoperative opioid consumption
Median difference
−0.07
95% CI −0.2 to 0.02
P = 0.026
By group
Methadone vs Morphine
median difference −0.07 (95% CI −0.2 to 0.02); P = 0.026
As reported in the abstract
Secondary outcomes
| Outcome | Methadone | Morphine | P value |
|---|---|---|---|
| Postoperative pain scoresNot significantly different | 3.5 (IQR 3.0–4.3) | 4.0 (IQR 3.2–5.0) | P = 0.250 |
Safety
Opioid-related side effects
- Groups did not differ
Original publication
Perioperative methadone for posterior spinal fusion in adolescents: Results from a double‐blind randomized‐controlled trial. Paediatr Anaesth. Published 30 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →