Hemodynamics, fluids & transfusion
Peripheral Administration of Norepinephrine: A Prospective Observational Study
Authors' conclusion
This study suggests that implementing a protocol for peripheral administration of norepinephrine safely can avoid 1 CVC day in the average patient, with 51.6% of patients not requiring CVC insertion.
Study context
- Population
- Adults in a medical ICU receiving norepinephrine through a peripheral IV catheter (PIVC), February 2019–June 2021
- Participants
- 635 adults
- Outcome
- Number of days of CVC use avoided per patient
Methodological detailssingle-centre, quaternary care academic medical center
- Single-centre
- Quaternary care academic medical center
Main finding
As reported in the abstract
CVC days avoided per patient
- Median central venous catheter (CVC) days avoided per patient (IQR 0-2 days)
- 1
Observational data: associations, not effects.
Further findings
Never required CVC insertion (603 with peripheral norepinephrine as first exposure)
- Patients never requiring CVC insertion, n (%)
- 311 (51.6%)
Safety
Extravasation of norepinephrine
- Patients with extravasation
- 35
- Extravasation events/1,000 d of PIVC infusion
- 75.8 (95% CI 52.8-105.4)
- Patients requiring surgical intervention
- 0
- Most extravasations caused no or minimal tissue injury
Original publication
Peripheral Administration of Norepinephrine: A Prospective Observational Study. Chest. Published 21 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →