Hemodynamics, fluids & transfusion
Peripherally administered vasopressin initiated in the emergency department
Authors' conclusion
With no observed instances of infiltration, extravasation, or other related complications, peripheral administration of vasopressin initiated in the ED for select, hemodynamically compromised patients may represent a feasible approach to initiate early vasopressor therapy while allowing clinicians to more carefully weigh the risks and benefits of CVC placement.
Study context
- Population
- Patients receiving peripheral vasopressin initiated in the emergency department (ED) of an academic tertiary medical center
- Participants
- 80 patients
- Outcome
- Incidence of reported infiltrations or extravasations after peripheral vasopressin
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Reported infiltration or extravasation with peripheral vasopressin
- No reports or incidents of infiltration or extravasation related to peripheral vasopressin
Observational data: associations, not effects.
Further findings
| Outcome | Values |
|---|---|
| Duration of peripheral vasopressin administration | Peripheral vasopressin median 444 (IQR 196–1314) min |
| Vasopressin rate | Peripheral vasopressin median 0.03 (IQR 0.03–0.04) units/min · minimum rate 0.01 units/min · maximum rate 0.08 units/min |
| Later transition to CVC administration | Peripheral vasopressin 32.5 % |
Safety
- No observed instances of infiltration, extravasation or other related complications
Original publication
Peripherally administered vasopressin initiated in the emergency department. J Crit Care. Published 27 November 2025. doi:10.
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