Persistence and Sexual Dimorphism of Gut Dysbiosis and Pathobiome after Sepsis and Trauma
Authors' conclusion
Dysbiosis induced by trauma and sepsis persists up to 14 to 21 days after onset and is sex-specific, underscoring the implication of pathobiome and entero-septic microbial-metabolite perturbations in post-sepsis and posttrauma chronic critical illness.
Study context
- Population
- Critically ill severe trauma and sepsis patients with chronic critical illness, 14 to 21 days after ICU admission, and healthy subjects
- Exposure
- Sepsis and trauma patients vs healthy subjects
- Outcome
- Persistence of intestinal microbiome dysbiosis and gut-plasma metabolomic perturbations
- Follow-up
- 14 to 21 days after ICU admission
Methodological detailsmulti-omics
- Multi-omics
Main finding
As reported in the abstract
Gut microbiome diversity and composition
- Strikingly depleted gut microbiome diversity, with significant alterations and specific pathobiome patterns in microbiota composition, in sepsis and trauma vs healthy subjects
Observational data: associations, not effects.
Further findings
Microbiome diversity by sex (subgroup)
- Resistance to changes in microbiome diversity among female trauma patients vs healthy counterparts
Fecal and plasma metabolites by sex (subgroup)
- Sex-specific changes in fecal metabolites after trauma and sepsis; plasma metabolite changes similar in males and females
Original publication
Persistence and Sexual Dimorphism of Gut Dysbiosis and Pathobiome after Sepsis and Trauma. Ann Surg. Published 12 June 2024. doi:10.
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