Respiratory failure & ventilation
Gut microbiota composition during hospitalization is associated with 60-day mortality after severe COVID-19
Main finding · 60-day mortality per baseline dysbiosis indexResult — go to the resultHazard ratio 3.70 CI 2.00–8.6Authors' conclusion
Although our data should be regarded as exploratory due to low number of clinical end points, they suggest that gut microbiota alterations during hospitalization could be related to poor prognosis after severe COVID-19.
Study context
- Population
- Hospitalized COVID-19 patients, Norwegian SARS-CoV2 cohort study50 sampled at 3 months
- Participants
- 123 patients
- Exposure
- Intensive care unit (ICU) vs Ward
- Outcome
- Association of ICU-related gut microbiota (dysbiosis index) with 60-day mortality
- Follow-up
- 60 days
Methodological detailsexploratory, subset of the Norwegian SARS-CoV2 cohort study, Rectal swabs within 48 h of admission and at 3 months; 16S rRNA gene sequencing
- Exploratory
- Subset of the Norwegian SARS-CoV2 cohort study
- Rectal swabs within 48 h of admission and at 3 months; 16S rRNA gene sequencing
Main finding
60-day mortality per baseline dysbiosis index
Hazard ratio
3.70
CI 2.00–8.6
P < 0.001
Dysbiosis index
HR 3.70 (CI 2.00–8.6); P < 0.001
Per baseline dysbiosis index, as printed
As reported in the abstract
Observational data: associations, not effects.
Further findings
Gut microbiota diversity (Shannon index) at baseline
- Lower in ICU than ward patients
Dysbiosis index and need of ICU admission · baseline
- Associated with ICU admission independent of antibiotics, dexamethasone, chronic pulmonary disease, PO2/FiO2, CRP, neutrophils, creatinine
- adjusted p < 0.001
Dysbiosis index at 3-month follow-up
- Remained elevated in ICU vs ward patients
- adjusted p = 0.007
Original publication
Gut microbiota composition during hospitalization is associated with 60-day mortality after severe COVID-19. Crit Care. Published 23 February 2023. doi:10.
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