ICU sedation, delirium & recovery
Persistent inspiratory muscle weakness among extubated patients after prolonged intubation is frequent and can be predicted early by maximal inspiratory pressure measured 12 days after its initial diagnosis: a prospective observational study
Authors' conclusion
Persistent IMW following prolonged MV is frequent throughout the acute care stay and until acute care hospital discharge. The MIP measured at day 12 after inclusion, as well as its change from inclusion to day 12, were strongly associated with persistent IMW.
Study context
- Population
- Intensive Care Unit (ICU) patients extubated after ≥ 7 days of mechanical ventilation (MV) with inspiratory muscle weakness (IMW, Maximal Inspiratory Pressure (MIP) ≤ 30 cmH2O) diagnosed within 48 h post planned extubationcompleted the study
- Participants
- Sixty-nine patients
- Exposure
- Persistent IMW vs No persistent IMW
- Persistent IMWn = 30
- Outcome
- Persistent IMW (MIP ≤ 30 cmH2O) at end of acute care hospital stay and associated factors
- Follow-up
- Study completion
Methodological detailsexploratory, multicentre (five Swiss hospitals)
- Exploratory
- Multicentre (five Swiss hospitals)
Main finding
As reported in the abstract
Persistent IMW
| Group | Value | Median MIP |
|---|---|---|
| Persistent IMW | 43% | 22 [13-24] cmH2O |
| No persistent IMW | median 44 (IQR 36–64) |
Value
Persistent IMW43%
No persistent IMWmedian 44 (IQR 36–64)
Median MIP
Persistent IMW22 [13-24] cmH2O
No persistent IMW— not stated in the abstract
Observational data: associations, not effects.
Original publication
Persistent inspiratory muscle weakness among extubated patients after prolonged intubation is frequent and can be predicted early by maximal inspiratory pressure measured 12 days after its initial diagnosis: a prospective observational study. Crit Care. Published 7 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →