Persistent severe acute kidney injury is a major modifiable determinant of outcome during critical illness
Authors' conclusion
Persistent severe AKI is an uncommon, but important complication in critically ill patients, associated with an increased risk of renal non-recovery, hospital readmission and death
Study context
- Population
- Critically ill patients with stage 2–3 acute kidney injury (AKI) admitted to one of 16 hospitals, October 2010 to June 2018stage 2–3 AKI of 190,550
- Participants
- 65,119 patients
- Exposure
- Persistent severe AKI vs no persistent severe AKI
- Persistent severe AKIn = 8,059
- Outcome
- Occurrence of persistent severe AKI
Methodological detailsmulticentre (16 hospitals)
- Multicentre (16 hospitals)
Main finding
As reported in the abstract
Persistent severe AKI
12.4%
8,059
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | |
|---|---|---|
| 90-day mortality | HR 1.5 (95% CI 1.4–1.6) | |
| Hospital readmission | OR 2.0 (95% CI 1.8–2.3) | |
| Renal recovery | OR 0.14 (95% CI 0.13–0.15) | |
| 0.10.31310Ratio (log scale) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Persistent severe acute kidney injury is a major modifiable determinant of outcome during critical illness. Intensive Care Med. Published 18 February 2025. doi:10.
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