Personalized automatic management of tracheal cuff pressure and subglottic secretions drainage to prevent pneumonia in critically ill intubated patients. The MICROINHALO multicenter randomized controlled trial
Primary resultResult — go to the resultAbsolute difference - 4 95% CI - 16 to 8Authors' conclusion
Among critically ill intubated patients, personalized automatic management of tracheal cuff pressure and subglottic secretion drainage was not superior to manual management to prevent tracheal colonization.
Study context
- Population
- Critically ill intubated adults in 10 ICUs250 analysed
- Participants
- 270 participants
- Comparison
- Automatic management vs Manual management
- Automatic managementn = 127
- Manual managementn = 123reference
- Primary endpoint
- Bacterial tracheal colonization (> 103 CFU/mL)
- Follow-up
- Day 3 after intubation
Methodological detailscluster-randomized, international, open-label, multicentre
- Cluster-randomized
- International
- Open-label
- Multicentre
Primary result
As reported in the abstract
Absolute difference
- 4
95% CI - 16 to 8
P = 0.52
Events by treatment group
Further findings
Clinically diagnosed VAP
P = 0.016
Microbiologically confirmed VAP
P = 0.039
Pcuff values outside the safety range
P < 0.001
Daily SSD volume · spread printed in brackets, kind not named
P < 0.001
Original publication
Personalized automatic management of tracheal cuff pressure and subglottic secretions drainage to prevent pneumonia in critically ill intubated patients. The MICROINHALO multicenter randomized controlled trial. Intensive Care Med. Published 2 June 2026. doi:10.
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