Cardiothoracic & vascular anesthesia
Pharmacokinetics of Methadone in Adult Patients Undergoing Cardiac Surgery With Cardiopulmonary Bypass
Authors' conclusion
Our results confirmed a decay in methadone concentrations during CPB, which, in our modeling analysis, was attributed to hemodilution and sequestration within the CPB components.
Study context
- Population
- Adults aged 45 to 75 years undergoing cardiac surgery with cardiopulmonary bypass (CPB), given IV methadone 0.2 mg/kg after anesthesia inductionall completed
- Participants
- 29 adults
- Exposure
- 10 minutes before CPB vs after 60 minutes of CPB
- Outcome
- Pharmacokinetics of an IV bolus of methadone racemate
Methodological detailsnonlinear mixed effects modelling, Arterial blood samples (n = 10) before, during and after CPB
- Nonlinear mixed effects modelling
- Arterial blood samples (n = 10) before, during and after CPB
Main finding
As reported in the abstract
Methadone concentrations
P < 0.001
- CPB effect best described by hemodilution in a fixed volume of 1.5 L (CPB circuit volume) and sequestration from CPB components (CL SEQ)
- 93.4 L/h, 95%CI 59-124, P < .01
Observational data: associations, not effects.
Original publication
Pharmacokinetics of Methadone in Adult Patients Undergoing Cardiac Surgery With Cardiopulmonary Bypass. Anesth Analg. Published 21 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →