Physical activity is associated with a lower risk of contracting and dying in infection and sepsis: a Swedish population-based cohort study
Authors' conclusion
Exercise and walking demonstrate inverse dose-response associations with both the risk of contracting and dying in infection and sepsis
Study context
- Population
- Participants of the Swedish Mammography Cohort and Cohort of Swedish Men, lifestyle questionnaires 1997, followed in national Swedish registers
- Participants
- 64,850 participants
- Exposure
- Exercise 1 h/week vs <1 h/week
- Outcome
- Contracting infection or sepsis and dying in infection or sepsis
Methodological detailsprospective, multivariable Cox regression
- Prospective
- Multivariable Cox regression
Main finding
As reported in the abstract
1 h/week vs <1 h/weekHazard ratio (95% CI)
Contracting infection or sepsis; adjusted
0.93(0.90–0.97)
Dying in infection or sepsis; adjusted
0.87(0.80–0.96)
- ≥1 episode of infection or sepsis (whole cohort)
- 26,124
- Died of infection or sepsis (whole cohort)
- 4708
Observational data: associations, not effects.
Further findings
Walking
- Similar patterns observed for walking
Population-attributable risk for not exercising
- Contracting infection or sepsis
- 2.6%
- Dying in infection or sepsis
- 4.5%
Original publication
Physical activity is associated with a lower risk of contracting and dying in infection and sepsis: a Swedish population-based cohort study. Crit Care. Published 24 March 2024. doi:10.
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