Respiratory failure & ventilation
Physiological comparison of noninvasive ventilation and Continuous Positive Airway Pressure (CPAP) on inspiratory efforts after extubation in critically ill patients with morbid obesity: a post-hoc analysis
Authors' conclusion
In critically ill post extubation patients with morbid obesity, both PSV-PEEP and CPAP reduced the inspiratory effort indexes including inspiratory work-of-breathing, traducing an unload of inspiratory muscles.
Study context
- Population
- Critically ill patients with morbid obesity after extubationmean BMI 45 kg/m²
- Participants
- 15 patients
- Comparison
- PSV-PEEP vs CPAP vs standard oxygen after extubation
- Primary endpoint
- Inspiratory efforts (trans-diaphragmatic pressure [Pdi] and work-of-breathing [work-of-breathing (WOB)])
- Follow-up
- 20 min after extubation
Methodological detailsconsecutive patients
- Consecutive patients
Primary result
As reported in the abstract
WOB
P < 0.001
Further findings
Swing Pdi — PSV-PEEP vs CPAP and standard oxygen · lower with PSV-PEEP
P < 0.001
Respiratory rate — PSV-PEEP and CPAP vs Standard oxygen · significant decrease
P < 0.05
RR/VT ratio — PSV-PEEP and CPAP vs Standard oxygen · significant decrease
P < 0.05
Original publication
Physiological comparison of noninvasive ventilation and CPAP on inspiratory efforts after extubation in critically ill patients with morbid obesity: a post-hoc analysis. Ann Intensive Care. Published 17 November 2025. doi:10.
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