Respiratory failure & ventilation
Physiological effects and safety of bed verticalization in patients with acute respiratory distress syndrome
Authors' conclusion
Verticalization to 90° is feasible in ARDS patients, improving EELV and oxygenation up to 30°, likely due to alveolar recruitment and blood flow redistribution.
Study context
- Population
- Early Acute Respiratory Distress Syndrome (ARDS) patients in two ICUs at CHU Clermont-Ferrand, France
- Participants
- 30 patients
- Exposure
- Stepwise bed verticalization vs 30° semi-seated baseline
- Outcome
- Variation in transpulmonary driving pressure through the verticalization procedure
Methodological detailstwo ICUs, single-centre, May 2020 through January 2021
- Two ICUs
- Single-centre
- May 2020 through January 2021
Main finding
As reported in the abstract
Transpulmonary driving pressure
P < 10-2
Observational data: associations, not effects.
Further findings
End-expiratory lung volume, alveolar strain, arterial oxygenation
- EELV increased with verticalization, with decreased alveolar strain and increased arterial oxygenation
Safety
Hemodynamic effects
- Procedure interrupted
- 2
- Decreased CO and stroke volume, increased norepinephrine doses and serum lactate with verticalization
Other adverse events (falls, accidental equipment removal)
- No other adverse events
Original publication
Physiological effects and safety of bed verticalization in patients with acute respiratory distress syndrome. Crit Care. Published 5 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →