Respiratory failure & ventilation
Physiological effects of high-flow nasal cannula oxygen therapy after extubation: a randomized crossover study
Authors' conclusion
Prophylactic application of HFNC after extubation provides substantial respiratory support and unloads respiratory muscles.
Study context
- Population
- Critically ill patients ventilated ≥48 h for acute respiratory failure, extubated after a successful spontaneous breathing trial (SBT)crossover
- Participants
- 22 patients
- Comparison
- 1 h high-flow nasal cannula (HFNC) vs 1 h standard oxygen after extubation
- Primary endpoint
- Respiratory effort (esophageal/transdiaphragmatic pressures) and diaphragm electrical activity (ΔEAdi)
Methodological detailsprospective
- Prospective
Primary result
As reported in the abstract
Respiratory effort
| Group | Value | Pressure-time product (cmH2O*s/min) | ΔEAdi (µV) |
|---|---|---|---|
| HFNC | 5.3 (range 4.2–7.1) cmH2O | 85 [67-140] | 10 [7-13] |
| Standard oxygen | 7.2 (range 5.6–10.3) cmH2O | 156 [114-238] | 14 [9-16] |
Value
HFNC5.3 (range 4.2–7.1) cmH2O
Standard oxygen7.2 (range 5.6–10.3) cmH2O
Pressure-time product (cmH2O*s/min)
HFNC85 [67-140]
Standard oxygen156 [114-238]
ΔEAdi (µV)
HFNC10 [7-13]
Standard oxygen14 [9-16]
- HFNC vs Standard oxygen: P < 0.001
- HFNC vs Standard oxygen: P < 0.001
- HFNC vs Standard oxygen: P = 0.022
Further findings
Lung volume, gas exchange, breathing pattern
- HFNC increased end-expiratory lung volume and PaO2/FiO2 ratio, and decreased respiratory rate and ventilatory ratio
Safety
Systemic hemodynamics and cardiac stress biomarkers (Troponin T, NT-proBNP)
- No changes observed
Original publication
Physiological effects of high-flow nasal cannula oxygen therapy after extubation: a randomized crossover study. Ann Intensive Care. Published 18 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →