Hemodynamics, fluids & transfusion
Pilot epinephrine dose-finding study to counter epidural-related blood pressure reduction
Authors' conclusion
Adding epinephrine to the epidural local anesthetic did not significantly decrease the rate of hypotension. However, epinephrine mitigated decreases in respiratory rate across the perioperative period.
Study context
- Population
- Patients receiving epidural analgesia47 completed
- Participants
- 66 patients
- Comparison
- Epidural ropivacaine 0.2% with 2 or 5 µg/mL epinephrine vs without epinephrine
- Controln = 15reference
- +2 µg/mLn = 16
- +5 µg/mLn = 16
- Primary endpoint
- Hypotension (>20% decrease from baseline to end of intraoperative period)
- Follow-up
- End of the intraoperative period
Methodological detailsquadruple-blinded, prospective, pilot, dose-finding, 19 withdrawn
- Quadruple-blinded
- Prospective
- Pilot
- Dose-finding
- 19 withdrawn
Primary result
As reported in the abstract
+2 µg/mL vs Control: P = 0.165 · +5 µg/mL vs Control: P = 0.353
- Overall rate of hypotension
- 21.3% (10/47)
Further findings
| Outcome | P value |
|---|---|
| Respiratory rate decrease across the perioperative periodControl vs +2 µg/mL and +5 µg/mL · greater decreases in control | P = 0.016 |
Original publication
Pilot epinephrine dose-finding study to counter epidural-related blood pressure reduction. Reg Anesth Pain Med. Published 11 July 2024. doi:10.
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