Plasma protein biomarkers reflective of the host response in patients developing Intensive Care Unit-acquired pneumonia
An erratum to this article was published (Crit Care, 1 Nov 2023 ↗)
Authors' conclusion
Critically ill patients who develop an ICU-acquired pneumonia, compared with those who do not, display alterations in plasma protein biomarker concentrations indicative of stronger proinflammatory, procoagulant and (injurious) endothelial cell responses.
Study context
- Population
- Patients on mechanical ventilation at Intensive Care Unit (ICU) admission with expected stay ≥48 h316 developed pneumonia (15.8%)
- Participants
- 1,997 patients
- Comparison
- Patients developing ICU-acquired pneumonia vs those who do not
- Casesn = 316
- Controlsn = 632reference
- Outcome
- 19 plasma host response biomarkers (inflammatory, endothelial, coagulation domains)
- Follow-up
- Study inclusion, day 7 and (cases) day of pneumonia diagnosis
Methodological detailsmulticentre, 30 hospitals in 11 European countries
- Multicentre
- 30 hospitals in 11 European countries
Main finding
As reported in the abstract
Plasma host response biomarkers
- Cases showed biomarker concentrations suggestive of enhanced inflammation and more disturbed endothelial barrier function at enrollment (median 2 days after ICU admission) and in the path to pneumonia diagnosis (median 5 days after ICU admission)
- Considerable variation across time points and patient groups
Observational data: associations, not effects.
Further findings
Baseline biomarker aberrations by timing of pneumonia onset (subgroup)
- Most profound in early pneumonia (< 5 days, n = 105) or late pneumonia (> 10 days, n = 68) after ICU admission
Original publication
Plasma protein biomarkers reflective of the host response in patients developing Intensive Care Unit-acquired pneumonia. Crit Care. Published 6 July 2023. doi:10.
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