Cardiothoracic & vascular anesthesia
Plasma Renin Activity Increases With Cardiopulmonary Bypass and is Associated With Vasoplegia After Cardiac Surgery
Authors' conclusion
In patients undergoing cardiac surgery on cardiopulmonary bypass, plasma renin activity increased postoperatively and remained elevated through postoperative day 2. Additionally, patients with vasoplegic syndrome after cardiac surgery on cardiopulmonary bypass had more robust elevations in plasma renin activity than nonvasoplegic patients.
Study context
- Population
- Adults undergoing cardiac surgery on CPB at a tertiary cardiac surgical institution, June 2020 to May 2021
- Participants
- 100 adults
- Exposure
- Vasoplegia vs no vasoplegia after CPB
- Outcome
- Plasma renin activity
Methodological detailssingle tertiary cardiac surgical institution
- Single tertiary cardiac surgical institution
Main finding
As reported in the abstract
- Median plasma renin activity increased ≈3 times from baseline immediately after surgery, remained elevated on POD 0, 1 and 2, began to downtrend on POD 3
- Plasma renin activity ≈3 times higher at all time points in patients with vasoplegia vs without
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Plasma Renin Activity Increases With Cardiopulmonary Bypass and is Associated With Vasoplegia After Cardiac Surgery. J Cardiothorac Vasc Anesth. Published 22 November 2022. doi:10.
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