Platelet aggregation and thromboelastometry monitoring in women with preeclampsia: a prospective observational study
Authors' conclusion
Platelet aggregation and thromboelastic tests of coagulation are dependent on platelet counts in women with preeclampsia. At normal platelet counts, women with preeclampsia have hyperactivated tests of coagulation. In contrast, women with thrombocytopenia demonstrated lower coagulation test values.
Study context
- Population
- Pregnant women with preeclampsia or normotensive pregnancies, sampled shortly before delivery
- Participants
- 93 vs 45
- Exposure
- Preeclampsia vs normotensive pregnancy
- Preeclampsian = 93
- Normotensiven = 45reference
- Outcome
- Platelet aggregation (impedance aggregometry) and coagulation (thromboelastometry)
- Follow-up
- Shortly before delivery
Methodological detailsGoPROVE Biobank and Database
- GoPROVE Biobank and Database
Main finding
As reported in the abstract
Platelet aggregation (ADP-, ASPI-, TRAP-test) and thromboelastometry
- No difference in platelet aggregation (ADP-, ASPI-, TRAP-test) between preeclampsia and normotensive pregnancies
- Preeclampsia: lower platelet counts, shorter clotting (EXTEM-CT, INTEM-CT) and clot formation (EXTEM-CFT, INTEM-CFT) times vs normotensive
Observational data: associations, not effects.
Further findings
Preeclampsia with normal platelet counts (subgroup)
- Platelet aggregation and coagulation hyperactivated
Preeclampsia with thrombocytopenia (subgroup)
- Platelet aggregation and thromboelastic coagulation tests impaired vs normotensive pregnancies
Original publication
Platelet aggregation and thromboelastometry monitoring in women with preeclampsia: a prospective observational study. Int J Obstet Anesth. Published 21 November 2024. doi:10.
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