Hemodynamics, fluids & transfusion
Platelet-sparing properties of aprotinin: A scoping review on mechanisms and clinical effects
Authors' conclusion
This review elucidated current knowledge on how aprotinin influences platelets and exerts its platelet-sparing effect, while highlighting gaps in the existing literature.
Study context
- Population
- Studies investigating a platelet-sparing effect of aprotinin (humans, patients or animals undergoing surgery; in-vitro studies of donated blood)
- Participants
- 64 studies
- Outcome
- Mechanisms of aprotinin's platelet-sparing effect
Methodological detailsMEDLINE, Embase and Cochrane searched from inception until 21 December 2023
- MEDLINE, Embase and Cochrane searched from inception until 21 December 2023
Main finding
As reported in the abstract
- Majority of studies observed a platelet-sparing effect, attributed to inhibition of platelet aggregation (protection of glycoprotein (GP) IIb/IIIa receptors), platelet adhesion (protection of GP Ib receptors), both aggregation and adhesion receptors, proteolysis of protease-activated receptor 1 receptors, platelet activation (inhibition of plasmin) and platelet activation (inhibition of thrombin)
Further findings
Dose-dependency of the platelet-sparing effect (in-vitro studies and RCTs)
- Mixed results
Relative contribution of platelet-sparing vs antifibrinolytic effect to reducing blood loss and transfusion
- No studies have explored this
Original publication
Platelet-sparing properties of aprotinin: A scoping review on mechanisms and clinical effects. Eur J Anaesthesiol. Published 11 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →